Ulcerative Colitis

Written by Francesca Testa

Ulcerative colitis (UC) falls under the category of inflammatory bowel disease (IBD), together with Crohn’s disease (CD). It is an idiopathic and autoimmune-mediated inflammation of the epithelial mucosa of the rectum and/or colon, which leads to a range of intestinal and extra-intestinal symptoms. Although not fully elucidated, its aetiology is thought to be multifactorial in origin, with both genetic predisposition and environmental factors playing a role in pathogenesis. UC is associated with a wide range of inflammatory conditions, including hepatic, gastrointestinal, musculoskeletal and cardiovascular comorbidities, and it is noticeably linked to mood disorders and anxiety. Management follows a step-up approach and aims to induce clinical remission and improve quality of life.

Clinical Features



Cellular Characteristics





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